Homme W Hellinga: search on Z-Library

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1

Genetic engineering of a single-chain antibody fragment for surface immobilization in an optical biosensor

Ronald T. Piervincenzi, William M. Reichert, Homme W. Hellinga

Journal:

Biosensors and Bioelectronics

Year:

1998

Language:

english

File:

PDF, 616 KB

english, 1998

2

The Crystal Structure of a Thermophilic Glucose Binding Protein Reveals Adaptations that Interconvert Mono and Di-saccharide Binding Sites

Matthew J. Cuneo, Anita Changela, Joshua J. Warren, Lorena S. Beese, Homme W. Hellinga

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.03 MB

english, 2006

3

Periplasmic binding proteins: a versatile superfamily for protein engineering

Mary A Dwyer, Homme W Hellinga

Journal:

Current Opinion in Structural Biology

Year:

2004

Language:

english

File:

PDF, 662 KB

english, 2004

4

Structural analysis, identification, and design of calcium-binding sites in proteins

Wei Yang, Hsiau-Wei Lee, Homme Hellinga, Jenny J. Yang

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2002

Language:

english

File:

PDF, 391 KB

english, 2002

5

Construction of new ligand binding sites in proteins of known structure: I. Computer-aided modeling of sites with pre-defined geometry

Homme W. Hellinga, Frederic M. Richards

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 2.75 MB

english, 1991

6

Synthesis and Characterization of a Ruthenium(II)-Based Redox Conjugate for Reagentless Biosensing

Trammell, Scott A., Goldston, Harold M., Tran, Phan T., Tender, Leonard M., Conrad, David W., Benson, David E., Hellinga, Homme W.

Journal:

Bioconjugate Chemistry

Year:

2001

Language:

english

File:

PDF, 64 KB

english, 2001

7

Construction of a fluorescent biosensor family

Robert M. De Lorimier, J. Jeff Smith, Mary A. Dwyer, Loren L. Looger, Kevin M. Sali, Chad D. Paavola, Shahir S. Rizk, Shamil Sadigov, David W. Conrad, Leslie Loew, Homme W. Hellinga

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 403 KB

english, 2002

8

Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry

Ladbury, John E., Kishore, Nand, Hellinga, Homme W., Wynn, Richard, Sturtevant, Julian M.

Journal:

Year:

1994

Language:

english

File:

PDF, 665 KB

english, 1994

9

Converting a Maltose Receptor into a Nascent Binuclear Copper Oxygenase by Computational Design †

Benson, David E., Haddy, Alice E., Hellinga, Homme W.

Journal:

Year:

2002

Language:

english

File:

PDF, 153 KB

english, 2002

10

The development of new biotechnologies using metalloprotein design

David E Benson, Michael S Wisz, Homme W Hellinga

Journal:

Current Opinion in Biotechnology

Year:

1998

Language:

english

File:

PDF, 646 KB

english, 1998

11

Structural Adaptations that Modulate Monosaccharide, Disaccharide, and Trisaccharide Specificities in Periplasmic Maltose-Binding Proteins

Matthew J. Cuneo, Anita Changela, Lorena S. Beese, Homme W. Hellinga

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.66 MB

english, 2009

12

Construction of a Novel Redox Protein by Rational Design: Conversion of a Disulfide Bridge into a Mononuclear Iron−Sulfur Center †

Benson, David E., Wisz, Michael S., Liu, Wentian, Hellinga, Homme W.

Journal:

Year:

1998

Language:

english

File:

PDF, 190 KB

english, 1998

13

RETRACTED: Local Encoding of Computationally Designed Enzyme Activity

Malin Allert, Mary A. Dwyer, Homme W. Hellinga

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 951 KB

english, 2007

14

Engineering Biosensors by Introducing Fluorescent Allosteric Signal Transducers: Construction of a Novel Glucose Sensor

Marvin, Jonathan S., Hellinga, Homme W.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 153 KB

english, 1998

15

Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates

Shahir S. Rizk, Matthew J. Cuneo, Homme W. Hellinga

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 262 KB

english, 2006

16

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

Weina Wang, Homme W. Hellinga and Lorena S. Beese

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

17

Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein

Yaji Tian, Matthew J. Cuneo, Anita Changela, Birte Höcker, Lorena S. Beese, Homme W. Hellinga

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 531 KB

english, 2007

18

In the wake of two retractions, a request for investigation

Hellinga, Homme W.

Journal:

Year:

2008

Language:

english

File:

PDF, 51 KB

english, 2008

19

Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins

Robert M. de Lorimier, Yaji Tian, Homme W. Hellinga

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 265 KB

english, 2006

20

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

Jillian Orans, Elizabeth A. McSweeney, Ravi R. Iyer, Michael A. Hast, Homme W. Hellinga, Paul Modrich, Lorena S. Beese

Journal:

Year:

2011

Language:

english

File:

PDF, 2.04 MB

english, 2011

21

Protein engineering and the development of generic biosensors

Homme W Hellinga, Jonathan S Marvin

Journal:

Trends in Biotechnology

Year:

1998

Language:

english

File:

PDF, 1.28 MB

english, 1998

22

Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor

Jonathan D. Dattelbaum, Loren L. Looger, David E. Benson, Kevin M. Sali, Richard B. Thompson, Homme W. Hellinga

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

23

Construction of a Blue Copper Analogue through Iterative Rational Protein Design Cycles Demonstrates Principles of Molecular Recognition in Metal Center Formation

Hellinga, Homme W.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 393 KB

english, 1998

24

Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity

Daniel G. Isom, Eyal Vardy, Terrence G. Oas, Homme W. Hellinga and David Baker

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

25

Dissection of the protein G B1 domain binding site for human IgG Fc fragment

David J. Sloan, Homme W. Hellinga

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 1.36 MB

english, 1999

26

Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics

Loren L. Looger, Homme W. Hellinga

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 296 KB

english, 2001

27

Thermodynamic Analysis of Ligand-Induced Changes in Protein Thermal Unfolding Applied to High-Throughput Determination of Ligand Affinities with Extrinsic Fluorescent Dyes

Layton, Curtis J., Hellinga, Homme W.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.63 MB

english, 2010

28

Engineering key components in a synthetic eukaryotic signal transduction pathway

Antunes, Mauricio S, Morey, Kevin J, Tewari-Singh, Neera, Bowen, Tessa A, Smith, J Jeff, Webb, Colleen T, Hellinga, Homme W, Medford, June I

Journal:

Molecular Systems Biology

Year:

2009

Language:

english

File:

PDF, 2.31 MB

english, 2009

29

Mutations in the active site of Escherichia coli phosphofructokinase

Hellinga, Homme W., Evans, Philip R.

Journal:

Year:

1987

File:

PDF, 359 KB

1987

30

An empirical model for electrostatic interactions in proteins incorporating multiple geometry-dependent dielectric constants

Michael S. Wisz, Homme W. Hellinga

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 346 KB

english, 2003

31

Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design

Mabanglo, Mark F., Hast, Michael A., Lubock, Nathan B., Hellinga, Homme W., Beese, Lorena S.

Journal:

Protein Science

Year:

2014

Language:

english

File:

PDF, 994 KB

english, 2014

32

The Rational Design and Construction of a Cuboidal Iron--Sulfur Protein

Christopher D. Coldren, Homme W. Hellinga and John P. Caradonna

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.24 MB

english, 1997

33

Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position

Ladbury, John E., Wynn, Richard, Hellinga, Homme W., Sturtevant, Julian M.

Journal:

Year:

1993

Language:

english

File:

PDF, 615 KB

english, 1993

34

Construction of a Catalytically Active Iron Superoxide Dismutase by Rational Protein Design

Ann L. Pinto, Homme W. Hellinga and John P. Caradonna

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.09 MB

english, 1997

35

The backbone structure of the thermophilicThermoanaerobacter tengcongensisribose binding protein is essentially identical to its mesophilicE. colihomolog

Matthew J Cuneo, Yaji Tian, Malin Allert, Homme W Hellinga

Journal:

BMC Structural Biology

Year:

2008

Language:

english

File:

PDF, 1.51 MB

english, 2008

36

Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium

Allert, Malin J., Hellinga, Homme W.

Journal:

Journal of Molecular Biology

Year:

2020

File:

PDF, 5.23 MB

2020

37

Harnessing environmental Ca 2+ for extracellular protein thermostabilization

Allert, Malin Jenny-Ann, Hellinga, Homme W.

Journal:

Year:

2020

File:

PDF, 1.28 MB

2020

38

Quantitation of protein–protein interactions by thermal stability shift analysis

Curtis J. Layton, Homme W. Hellinga

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 711 KB

english, 2011

39

A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity

Daniel G. Isom, Philippe R. Marguet, Terrence G. Oas, Homme W. Hellinga

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2011

Language:

english

File:

PDF, 1.99 MB

english, 2011

40

Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms

J. Jefferson Smith, David W. Conrad, Matthew J. Cuneo, Homme W. Hellinga

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 325 KB

english, 2005

41

Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase

Homme W. HELLINGA, Philip R. EVANS

Journal:

Year:

1985

Language:

english

File:

PDF, 1.00 MB

english, 1985

42

Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein–protein interactions directly from DNA

Curtis J. Layton, Homme W. Hellinga

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 409 KB

english, 2011

43

Computational design of receptor and sensor proteins with novel functions

Looger, Loren L., Dwyer, Mary A., Smith, James J., Hellinga, Homme W.

Journal:

Year:

2003

Language:

english

File:

PDF, 445 KB

english, 2003

44

The construction of metal centers in proteins by rational design

Homme W Hellinga

Journal:

Folding and Design

Year:

1998

Language:

english

File:

PDF, 161 KB

english, 1998

45

Design of a Calcium-Binding Protein with Desired Structure in a Cell Adhesion Molecule

Yang, Wei, Wilkins, Anna L., Ye, Yiming, Liu, Zhi-ren, Li, Shun-yi, Urbauer, Jeffrey L., Hellinga, Homme W., Kearney, Alice, van der Merwe, P. Anton, Yang, Jenny J.

Journal:

Journal of the American Chemical Society

Year:

2005

Language:

english

File:

PDF, 581 KB

english, 2005

46

Protein fabrication automation

J. Colin Cox, Janel Lape, Mahmood A. Sayed, Homme W. Hellinga

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 830 KB

english, 2007

47

Multifactorial Determinants of Protein Expression in Prokaryotic Open Reading Frames

Malin Allert, J. Colin Cox, Homme W. Hellinga

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

48

Mapping Staphylococcal Nuclease Conformation Using an EDTA-Fe Derivative Attached to Genetically Engineered Cysteine Residues

Ermacora, Mario R., Ledman, David W., Hellinga, Homme W., Hsu, Gene W., Fox, Robert O.

Journal:

Year:

1994

Language:

english

File:

PDF, 4.26 MB

english, 1994

49

Structural Reorganization and Preorganization in Enzyme Active Sites: Comparisons of Experimental and Theoretically Ideal Active Site Geometries in the Multistep Serine Esterase Reaction Cycle

Smith, Adam J. T., Müller, Roger, Toscano, Miguel D., Kast, Peter, Hellinga, Homme W., Hilvert, Donald, Houk, K. N.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 1.48 MB

english, 2008

50

NMR studies of structure, hydrogen exchange, and main-chain dynamics in a disrupted-core mutant of thioredoxin

Robert De Lorimier, Homme W. Hellinga, Leonard D. Spicer

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 2.19 MB

english, 1996

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